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Figure 1: Typical domain organization of NRs, showing, in purple, the N-terminal domain, harboring the activation function ligand independent (AF-1); in light brown, the DNA binding domain, responsible for DNA binding; in light green, the hinge, which connects DBD and LBD; in yellow, the ligand binding domain (LBD) with the activation function ligand dependent (AF-2); and, in pink, the C-terminal portion.