|Figure 2: Illustration of the nuclear receptors' DBD. DBD is shown in dimeric form (in purple
and pink) with two zinc ions (in gray) coordinated to each monomer bound to DNA (PDB:
1HCQ modified). On the right side, details of the two zinc fingers, each one being
coordinated by four cysteines. Helix 1 or the recognition α-helix shown in light pink
comprises the P box. The second zinc finger comprises residues forming the highlighted
D box or dimerization interface. Finally, helix 2 is shown in red in the carboxiterminal
extension (CTE). Adapted from 21.