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Figure 2: Illustration of the nuclear receptors' DBD. DBD is shown in dimeric form (in purple and pink) with two zinc ions (in gray) coordinated to each monomer bound to DNA (PDB: 1HCQ modified). On the right side, details of the two zinc fingers, each one being coordinated by four cysteines. Helix 1 or the recognition α-helix shown in light pink comprises the P box. The second zinc finger comprises residues forming the highlighted D box or dimerization interface. Finally, helix 2 is shown in red in the carboxiterminal extension (CTE). Adapted from 21.