|Figure 1: Model of GR and MR action: the adipogenic media contain DEXA, IBMX, and insulin and
are supplemented with fetal bovine serum. Upon corticosteroid hormone binding to its
receptor (GR or MR) FKBP51 is exchanged for FKBP52 that facilitates the retrograde
movement of the NR towards the nucleus. IBMX increases cAMP leading to PKA activation
that triggers the translocation of FKBP51 from mitochondria to the nucleus, possibly
upon changes in its phosphorylation status. In the nucleus GR binds to its target
genes, localizing in the NL (nuclear lamina) and possibly in the NM (nuclear matrix).
FKBP51 is retained in the nucleus by its interaction with the NL, the NM, and chromatin,
regulating GR-target genes and possibly other genes.