Table 2: Selected genes validated by RT-PCR.


Gene Name Function

GLIPR2 Glioma pathogenesis- related 2 The product of this gene increases the activation of fibroblasts and induces epithelial mesenchymal transition (Baxter et al., 2007).
IL7R Interleukin 7 receptor High levels of this receptor correlate with tumor aggressiveness in breast cancer (Al- Rawi et al., 2004).
SREBF1 Sterol regulatory element binding transcription factor It has been found to be involved in signaling pathways related to cancer (Shao and Espenshade, 2012).
IL18 Interleukin 18 This cytokine is involved in carcinogenesis and it is secreted by tumor cells, e.g., kidney (Sözen et al., 2004) and prostate cancer (Binay Lebel et al., 2003).
TGF β2 Transforming growth factor β-2 Disruption of this gene function has been implicated in a variety of cancers (Buck and Knabbe, 2006; Nilsson EE, Skinner MK, 2002; Steiner, 1995 )
MAP1B Microtubule-associated protein 1B This gene encodes a protein that belongs to the microtubule-associated protein family, which are involved in microtubule assembly. (Riederer, 2007).
ANLN Anillin, actin binding protein Alterations in this gene have been linked to oral cancer. Its upregulation is a common feature in the carcinogenic process of lung tissue (Suzuki et al., 2005).
HBG1 Hemoglobin, gamma A This gene product is part of the fetal hemoglobin. It has been reported that some therapies directed to differentiate malignant cells result in the synthesis of fetal hemoglobin (Patrinos et al, 2005; Kieslich et al, 2003).
STARD4 STAR-related lipid transfer (START) domain containing The level of expression of this gene has been linked to the endoplasmic reticulum stress (Yamada et al., 2006).
AOC3 Amine oxidase, copper It has been associated with migration and metastasis in cancers such as colorectal, prostate, and melanoma (Jalkanen and Salmi, 2007; Toiyama, et al, 2009;. Ekblom et al, 1999. Forster-Horváth et al, 2004).