Over the period, due to evolutionary constrains, gene mutations, changes in microand mega-environment bacteria change their morphological features to adopt in the hostile environment. When they are exposed with broad spectrum antibiotics, they have adopted to live and become resistant to antibiotics. In this review many preventive and curative strategies has been described to avoid antibiotics. This would not give chances to microbes to become drug resistant. “Prevention is better than cure” adopting this strategy we have described immunochemical and many herbal medicines which will prevent infections. Also given importance to maintain proper balance of macrobiotic in the gut by replacement of the lost (may be due to many reasons) species.
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