The Open Access Journal of Science and Technology

Abstract

Cellular Mechanisms of Oestrogen in Breast Cancer Development

Author(s): Olugbenga T. Awolaran

The associationbetweenoestrogenandbreastcancerhasbeendemonstratedforoveracenturyhowevertheexactcellular mechanismsbywhichoestrogenplayaroleinbreastcancerdevelopmenthasnotbeenfullyestablished.Recentinvestigationshave shownthatoestrogenisinvolvedinmanyaspectsofcancerprogression.Thisreviewevaluateshowoestrogenatthecellularlevel inducesorpromotestheprocessofbreastcarcinogenesisthroughitsactionatmultiplelevelsofcancerpathogenesislikecellular proliferation,inhibitionapoptosis,angiogenesisandinvasion-metastasis.Therapeuticapproachesagainstthesemechanismsbythe useofanti-oestrogensandtheireï¬Â€ectivenessarealsoreviewedandareasrequiringfurtherinvestigationarehighlighted

Share this article