Figure 1: MYC proteins function as sequence-specific transcriptional regulators. The image shows a cartoon of the MYC protein, which carries an amino-terminal (N) transcriptional activation domain (TAD) and forms a functional DNA-binding domain (DBD) via association with MAX. MYC/MAX heterodimers bind variants of the E-box motif, which can be found in promoters as well as transcribed portions of MYC target genes. MAX does not carry a TAD. The image also shows some of the transcriptional effector molecules and complexes that have been shown to mediate various actions of MYC on gene expression.