Figure 8: Enhancers versus super-enhancers have different dose-dependent properties.Theoretical dose-response curve for a typical enhancer (left) or a super-enhancer (right). As the concentration of a positively acting factor (activator) increases, the enhancer without cooperative protein-protein interactions responds linearly. The super-enhancer, in contrast, is built via cooperative interactions among enhancers, and thus displays a sigmoidal response. In this case, a small change in the concentration of the activator results in a proportionately larger response in enhancer function and transcriptional output. Adapted from [105].