Figure 9: The impact of histone modification on genome recognition by MYC proteins. (A) Two genes (X and Y) are presented in two cell types (1 and 2), both of which have identical E-box elements. In Cell #1, Gene X carries the permissive H3K4me3 mark on an adjacent nucleosome, binds MYC/MAX dimers, and is induced by MYC. In Cell #2, which is geneticallyidentical, the pattern of H3K4me3 modification is reversed, and Gene Y binds MYC/MAX. (B–C) Two models for how H3K4me3 promotes MYC binding to chromatin. In (B), the H3K4me3 modification induces structural changes in how the E-box is presented (dotted lines), allowing MYC/MAX heterodimers to bind. In (C) the H3K4me3 modification recruits a methyllysine binding protein (MBP) that recognizes both the modified histone and MYC, actively recruiting MYC/MAX heterodimers to the site.