Willem van Berkel has made major contributions in the biochemistry, biocatalysis and chemical biology of (redox) enzymes. In his research group Enzymes@Work he focuses on the discovery, mechanisms, and state-of-the-art engineering of (redox) enzymes for applications in food, health, technology and environment. Mechanistic and structural insights are combined with catalytic applications at laboratory scale. A main strategy involves protein engineering efforts directed at understanding and improving the capabilities of oxidative biocatalysts. In addition to his scholarly work, he has made important contributions to the community through his service on the Netherlands Organization for Scientific Research (NWO), the Dutch Society of Biochemistry and Molecular Biology (NVBMB), and the Federation of the European Biochemical Society (FEBS). He is also a dedicated teacher, mentoring graduate students and postdoctoral associates while teaching biological chemistry, enzymology and applied biocatalysis to undergraduates.