Dr. Long-sen Chang received his Ph.D. degree in Taiwan National Tsing Hua University 1989. He is now a full time faculty in Institute of Biomedical Sciences in National Sun Yat-Sen University in Taiwan. Dr. Chang has paid his efforts on studying structure-function relationship and genetic structure of snake venom proteins over 30 years. Moreover, Dr. Chang extends his studies on rational drug design using snake proteins as a template. He is also interested in translational medicine including signaling pathways on carcinogenesis and anti-tumor therapy. He and his colleagues determine the genetic structure of snake venom phospholipase A2 enzymes, neurotoxins and cardiotxins and suggest a common pathway for the evolution of snake venom proteins. Recently, Dr. Chang studies the leukemia therapy focusing on the modulation of ADAM and MMP activity.