The Open Access Journal of Science and Technology

Abstract

Investigating the Effects of Mild Induced Hypothermia on Cognition using a Measure of Sustained Attention

Author(s): EricA.Lacey,RedmondG.O’Connell,ShaneM.O’Mara,andPaulM.Dockree

MildInducedhypothermiahascometoberecognisedasasuccessfulmethodofprovidingneuro-protectivetreatmentfor patientssufferingischemicstroke,cardiacarrestandtraumaticbraininjury(TBI).Anti-inflammatoryresponsesandthelowering of cerebral metabolic rates, leading to a reduction in neuronal apoptosis, are considered to be the main mechanisms by which this process benefits patients. Assessment of a new hydro based cooling device, which could potentially be used by emergency serviceunits,providedtheimpetusforthecurrentresearch.Neurologicallynormalparticipantsunderwenttwotreatments:acooling procedurewherethetemperatureofwatercirculatinginacoolinghelmetwasmaintainedat4∘Candanon-cooling/shamprocedure wherethetemperaturewassetat18∘C.Duringtreatmentparticipantswererequiredtoperformacomputer-basedtaskthatmeasured sustained attention/vigilance via participant response times during target detection. Electroencephalographic (EEG) recordings werealsoacquiredbeforeandaftereachtreatmentcondition.Participants’coretemperature(recordedviatympanicmembrane) was monitored throughout the process. The findings revealed a statistically reliable 0.62∘C decrease in temperature as a result ofcoolingaftercontrollingforparticipants’bodymassindex(BMI).However,therewerenoreliablecognitiveorEEGspectral changesinducedbythedecreaseintemperature.

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